Template:Anticholinergic Toxicity Treatement

1. GI decon
   1. Activated Charcoal may be effective even >1hr after ingestion (decreased GI motility)
2. Sedation
   1. Decreases the risk of hyperthermia, rhabdo, traumatic injuries
   2. Benzos are agents of choice especially increase seizure threshold
3. Cholinesterase inhibition
   1. Indicated for severe agitation or delirium (esp if unresponsive to benzos)
   2. Avoid when cardiac conduction abnormalities are present
   3. Physostigmine
      1. Dosing: 0.5-2mg IV over 5min
      2. Onset of action: 15-20min
      3. Side effects: bradycardia, dysrhythmias, cholinergic excess
      4. always have atropine at the bedside for bradycardia or cholinergic excess