Amoxicillin

General

• Type: Amino-Penicillin
• Dosage Forms: 250, 500, 875; 125, 200, 250, 400/5 mL
• Common Trade Names: Amoxil; Moxatag

Adult Dosing

General

• 500-875 mg PO q12

Strep Pharyngitis

• 1000 mg PO q24h x 10 days

Otitis Media

• 1000 mg PO q8h x 10 days

Sinusitis

• 1000 mg PO q8h x 10 days

Dental Abscess

• 1000 mg PO x 1, then 500 mg PO q8h x 3 days
• If I&D

Chlamydial Cervicitis/Urethritis

• 500 mg PO q8h x 7 days
• For pregnant patients

Lyme Disease

• 500mg PO q8h x 14-21 days

Salmonella

Not 1st line treatment

• Acute
  • Immunocompetent
    • 500mg PO q8h x 3-7 days
  • Immunocompromised
    • 1000mg PO q8h x 3-14 days
• Chronic carrier
  • 1000mg PO q8h x 3 months

Typhoid Fever

Not 1st line treatment

• 50-100 mg/kg/day PO divided q6-8h x 14 days
• First Dose: 12.5mg-33.3 mg/kg PO x 1

Pediatric Dosing

General

• <3mo: 20-30 mg/kg/day PO divided q12h
  • First Dose: 10-15 mg/kg PO x 1
  • Max: 30 mg/kg/day
• >3mo: 25-45 mg/kg/day PO divided q12h
  • First Dose: 12.5-22.5 mg/kg PO x 1
  • Max: 875 mg/dose

Otitis Media

• <2 months
  • 30 mg/kg/day PO divided q12h x 10 days
  • First Dose: 15 mg/kg PO x 1
• 2 months - 5 years
  • 80-90 mg/kg/day PO divided q12h x 10 days
  • First Dose: 40-45 mg/kg PO x 1
  • Max: 1000 mg/dose
• 6-12 years
  • 80-90 mg/kg/day PO divided q12h x 5-10 days
  • First Dose: 40-45 mg/kg/day PO x 1
  • Max: 1000 mg/dose

Community Acquired Pneumonia

• 90 mg/kg/day PO divided q12h x 5-10 days
• First Dose: 45 mg/kg PO x 1
  • Max
    • 3 months - 4 years: 500 mg/dose
    • >5 years: 4000 mg/day

Strep Pharyngitis

• 50 mg/kg Po q24h x 10 days
• Max: 1000 mg/day

Sinusitis

• 90 mg/kg/day PO divided q8-12h x 10 days
• Max: 1000 mg/dose

H. pylori

• 50 mg/kg/day PO divided BID x 7-14 days
• Max: 2000 mg/day

Early Lyme Disease

• 50 mg/kg/day PO divided q8h x 14-21 days
• First Dose: 16.6 mg/kg PO x1
• Max: 500 mg/dose

Salmonella (>3mo)

• 50-100 mg/kg/day PO divided q8-12h
  • Acute: x 3-7 days
  • Acute Immunocompromised: 10-14 days
  • Chronic: 3 months

Typhoid Fever (>3mo)

Not 1st line treatment

• 50-100 mg/kg/day PO divided q6-8h x 14 days

Special Populations

• Pregnancy Rating: B
• Lactation: Use caution
• Renal Dosing
  • Adult
  • Pediatric
• Hepatic Dosing
  • Adult
  • Pediatric

Contraindications

• Allergy to class/drug

Pharmacology

• Half-life:
• Metabolism:
• Excretion:
• Mechanism of Action:

See Also

• Antibiotics (Main)