Dilantin Load

First time load: 18mg/kg (can be given PO in divided doses or IV)

If patient is already on dilantin but sub-therapeutic use following to calculate dose needed to achieve therapeutic level:

Concentration adjusted = (concentration desired - concentration measured) x (0.7 x adjusted body weight)

Sheiner-Tozer Equation may be needed to correct level in patients with low albumin or abnormal creatinine:

• Corrected level = measured level/[(adjustment x albumin) + 0.1]
• adjustment is 0.2 unless patient has Creatinine clearance <20 then it is 0.1

See Also

Neuro: Seizure (Reloading)