Cephalosporins
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Template:Clinically Active Antibiotics
- 1st Gen Cephalosporins
- Cefazolin, Cephalexin
- Skin and soft tissue infections (why is agent of choice before gen sx)
- Cross-reactivity of PCN allergy <10%
- Cefazolin, Cephalexin
- 2nd Gen Cephalosporins
- Cefuroxime
- Intestinal anaerobes (why is agent of chioce for colorectal sx)
- Largely displaced by 3rd gen agents
- Cefuroxime
- 3rd Gen Cephalosporins
- Ceftriaxone, Ceftazidime, Cefixime
- Drug of choice for serious infections due to:
- Klebsiella
- Enterobacter
- Proteus
- Haemophilus
- Gonorrhea
- Lyme disease
- Meningitis (+ vanc and ampicillin)
- Pseudomonas meningitis (+ AG)
- Drug of choice for serious infections due to:
- Ceftriaxone, Ceftazidime, Cefixime
- 4th Gen Cephalosporins
- Cefepime
- Resistant, nosocomial infections
- Cefepime
- Carbapenems
- Imipenem (+ cilastatin), meropenem
- Cephalosporin-resistant nosocomial bacteria
- Empirical treatment of serious infections in patients who recently received other b-lactams
- Imipenem (+ cilastatin), meropenem
- Aztreonam
- Antimicrobial activity more closely resembles AG's (only active against gram -)
- Enterobacter, pseudomonas, H. influenzae, gonococci
- Little allergic cross-reactivity with B-lactam antibiotics
- Antimicrobial activity more closely resembles AG's (only active against gram -)
See Also
Source
Goodman & Gilman's Pharmacology