Camphor toxicity

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Background

  • Common topical agent for pain relief, wart removal, osteoarthritis, cold sores, cough suppression, nasal decongestion
  • FDA limits over the counter preparations to 11%[1]
  • Highly lipophilic, widely and rapidly distributed, symptom onset 5-15 minutes
  • CNS stimulant when ingested

Clinical Features

  • Nausea, vomiting, abdominal pain
  • Oral burning, headache
  • Vertigo, confusion, agitation
  • Seizure, respiratory depression, coma
  • Hepatitis and liver failure

Differential Diagnosis

Evaluation

Management

  • Aggressive supportive care[2]
  • Benzodiazepines for seizure
  • Intubation and mechanical ventilation as needed
  • Charcoal not likely effective

Disposition

See Also

References

  1. ↑ United States Food and Drug Administration. Proposed rules: external analgesic drug products for over-the-counter human use; tentative final monograph. Fed Reg 1983
  2. ↑ American Academy of Pediatrics Policy Statement. Camphor Revisited: Focus on Toxicity (RE9422). Pediatrics 1994;94:127-128
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