Vasopressin

General

• Type: Vasopressors
• Dosage Forms:
• Common Trade Names:

Adult Dosing

Dosing

• 0.04 units/min

Rate of Titration

• Fixed dose (do not titrate)

Pediatric Dosing

0.0002–0.008 U/kg/min have been studied although no current consensus on dosage

Special Populations

• Pregnancy Rating:
• Lactation:
• Renal Dosing
  • Adult
  • Pediatric
• Hepatic Dosing
  • Adult
  • Pediatric

Contraindications

• Allergy to class/drug

Adverse Reactions

• Bradycardia
• Limb ischemia
• Myocardial ischemia
• Splanchnic ischemia

Pharmacology

• Half-life:
• Metabolism:
• Excretion:
• Mechanism of Action:

Primary Receptor

• V1

Relative Effects

• ↑SVR
• ↓HR

Notes

• Adverse effects are dose-dependent
• Acts on V1 receptors leading to ↑vasoconstriction and

↑sensitivity to catecholamines in patients with shock

Indication

• Adjunct for septic shock