Template:Vasopressor table

Vasopressors

Pressor	Initial Dose	Max Dose	Cardiac Effect	BP Effect	Arrhythmias	Special Notes
Dobutamine	2.5 mcg/kg/min	10-40 mcg/kg/min	mainly inotrope (ß1)	alpha effect minimal	Some HR(ß1) increase. Also Increase SA and AV node fx	Debut Research 1979 Isoproterenol has most Β2 vasodilatory and Β1 HR effects
Dopamine	2 mcg/kg/min	20-50 mcg/kg/min	β1 and NorEpi release	α effects if > 20mcg/kg/min	Arrhythmogenic from β1 effects	More adverse events when used in shock compared to Norepi
Epinepherine	0.1-1 mcg/kg/min
Norepinephrine	8-12 mcg/min	30 mcg/min	β1 direct effect	β1 and α1,2 effects	Less arrhythmias than Dopamine	Increases MAP, coronary perfusion pressure, little β2 effects.
Milrinone	50 mcg/kg x 10 min	0.375-75 mcg/kg/min	Direct influx of Ca2+ channels	Smooth muscle vasodilator		PDE Inhibitor which increases Ca2+ uptake by sarcolemma. No venodilatory activity
Phenylephrine	100-180 mcg/min then 40-60 mcg/min	0.4-9 mcg/kg/min		Alpha agonist		Long half life
Vasopressin	Fixed Dose	0.4 U/min	unknown	increases via ADH peptide		should not be titrated due to ischemic effects
Methylene blue	IV bolus 2 mg/kg over 15 min	1-2 mg/kg/hour	Possible increased inotropy, cardiac use of ATP	Inhibits NO mediated peripheral vasodilation		Don't use in G6PD deficiency, ARDS, pulmonary hypertension

Medication	IV Dose (mcg/kg/min)	Concentration
Norepinephrine (Levophed)	0.1-2 mcg/kg/min	8mg in 500mL D5W
Dopamine	2-20 mcg/kg/min	400mg in 250 D5W
Dobutamine	2-20 mcg/kg/min	250mg in 250 mg D5W
Epinephrine	0.1-1 mcg/kg/min	1mg in 250 D5W