Cocaine
Revision as of 19:35, 18 February 2017 by Rossdonaldson1 (talk | contribs)
This page is for the drug cocaine; for clinical effects see cocaine toxicity
Administration
- Type:
- Dosage Forms:
- Routes of Administration:
- Common Trade Names:
Adult Dosing
Pediatric Dosing
Special Populations
- Pregnancy Rating:
- Lactation risk:
Renal Dosing
- Adult:
- Pediatric:
Hepatic Dosing
- Adult:
- Pediatric:
Contraindications
- Allergy to class/drug
Adverse Reactions
- Acute
- Cocaine-associated chest pain
- Sympathomimetic qualities
- Tachycardia
- Fever
- Agitation
- Diaphoresis
- Pulmonary Complications:
- "Crack lung"[1]
- Diffuse alveolar hemorrhage[2]
- ARDS
- Acute eosinophilic pneumonia
- Pneumothorax
- Pneumomediastinum
- Thermal epiglottitis - hot cocaine
- Chronic
- Atherosclerosis
- Cardiomyopathy
- Nasal Septum damage
- Up to 70% of US cocaine tainted with levamisole, potentially leading to neutropenia, vasculitis
Pharmacology
- Half-life:
- Metabolism:
- Excretion:
Mechanism of Action
- Blocks reuptake of serotonin, dopamine and norepinephrine
- Anesthetic effects achieved through sodium channel blockade
Comments
See Also
References
- ↑ Forrester, J. M., Steele, A. W., Waldron, J. A. and Parsons, P. E. (1990) ‘Crack Lung: An Acute Pulmonary Syndrome with a Spectrum of Clinical and Histopathologic Findings’, American Review of Respiratory Disease, 142(2), pp. 462–467. doi: 10.1164/ajrccm/142.2.462.
- ↑ Ettinger, N. A. and Albin, R. J. (1989) ‘A review of the respiratory effects of smoking cocaine’, The American Journal of Medicine, 87(6), pp. 664–668. doi: 10.1016/s0002-9343(89)80401-2.