Micafungin

Administration

• Type: Antifungal
• Dosage Forms:
• Routes of Administration: Intravenous
• Common Trade Names:

Adult Dosing

• Candidiasis or aspergillosis treatment: 50-150mg IV daily
• Antifungal prophylaxis: 1mg/kg IV daily

Pediatric Dosing

• <4mo, <40kg: 2-3mg/kg IV daily
• <4mo, >40kg: 100-150 mg IV daily

Special Populations

• Pregnancy Rating: C
• Lactation risk: Infant risk cannot be ruled out
• Renal dosing: no adjustment
• Hepatic dosing: no adjustment

Contraindications

• Allergy to class/drug

Adverse Reactions

Serious

• Atrial fibrillation, MI, pericardial effusion, cardiac arrest
• Anemia, hemolysis
• Liver failure, hepatitis
• Encephalopathy
• Intracranial hemorrhage
• Seizure
• Acute renal failure

Common

• Nausea, vomiting, diarrhea
• Headache
• Fever
• Thrombocytopenia

Pharmacology

• Half-life: 5.5-21h
• Metabolism: Hepatic, mostly CYP3A
• Excretion: Mostly fecal

Mechanism of Action

• Inhibits the synthesis of vital fungal cell wall component 1,3 beta-D-glucan

See Also

• Antifungal
• Candidiasis, Aspergillosis