Docusate

Administration

• Type: stool softener
• Dosage Forms:
• Routes of Administration: Oral, rectal
• Common Trade Names: Colace

Adult Dosing

• 50 to 200 mg daily or in 2-4 divided doses

Pediatric Dosing

• <3y: 10 to 40 mg/day in 1-4 divided doses
• 3-6y: 20 to 60 mg/day in 1-4 divided doses
• 6-12y: 40 to 120 mg/day in 1-4 divided doses

Special Populations

• Pregnancy Rating: A
• Lactation risk: Infant risk cannot be ruled out

Renal Dosing

• Adult:
• Pediatric:

Hepatic Dosing

• Adult:
• Pediatric:

Contraindications

• Allergy to class/drug
• Acute obstruction
• Acute abdominal pain, vomiting
• concurrent use of mineral oil

Adverse Reactions

Serious

• Hepatotoxicity (Rare)

Common

• Diarrhea, nausea, cramping

Pharmacology

• Half-life:
• Metabolism:
• Excretion:

Mechanism of Action

• Draws water into stool

See Also

• Constipation
• Lactulose