Opioid toxicity

Revision as of 02:20, 5 January 2012 by Jswartz (talk | contribs)

Background

  • Obtain acetaminophin levels in all cases of combination opioid-acetaminophen overdoses
  • Respiratory depression is the cause of all mortality from opioid toxicity

Clinical Features

  • Miosis
  • N/V
  • Respiratory depression
  • Mental status depression

DDX

  1. Clonidine toxicity
  2. Organophosphate toxicity
  3. Sedative-hypnotic toxicity
  4. CO poisoning
  5. Hypoglycemia
  6. Postictal state
  7. CVA


Treatment

Narcan (initial Dose 0.4 to 2mg)

Caution in chronic users, who are otherwise hemodynamically stable


Narcan gtt started at 2/3 the dose first required to awaken the patient per hour


Diagnosis

Source

  • Tintinalli
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