Acetazolamide
General
- Type: Carbonic anhydrase inhibitor
- Dosage Forms: PO/IV
- Common Trade Names: Diamox
Adult Dosing
Pediatric Dosing
Special Populations
- Pregnancy Rating: C
- Lactation risk: Safe
- Renal Dosing
- Adult: CrCl 10-50: give q12h; CrCl<10: avoid use; HD/PD: not defined
- Pediatric: CrCl 10-50: give q12h; CrCl<10: avoid use, HD/PD: not defined
- Hepatic Dosing
- Adult: contraindicated in significant impairment/cirrhosis
- Pediatric: contraindicated in significant impairment/cirrhosis
Contraindications
- Allergy to class/drug
- hypokalemia
- hyponatremia
- acidosis, hyperchloremic
- acidosis, metabolic
- adrenal insufficiency
- cirrhosis
- hepatic disease, severe
- renal disease, severe
- glaucoma, angle-closure (long-term use)
- caution if hypersensitivity to sulfonamides
- caution if ASA tx, high-dose
- caution if hepatic impairment
- caution if pulmonary impairment
- caution if diabetes mellitus
- caution if gout
- caution if elderly pts
Adverse Reactions
Serious
Common
Pharmacology
- Half-life: 10-15h
- Metabolism: CYP450
- Excretion: urine (100% unchanged)
- Mechanism of Action: inhibits carbonic anhydrase