Digoxin
Adult Dosing
- Loading dose = 0.25 mg IV q2hr until effect (max total = 1.5 mg)
- in acute afib rvr with heart failure = 0.5 mg IV, then 0.25 mg IV q4hr until effect or max 1.5mg
Contraindications
- WPW
- Increases conduction velocity in atrial tissue
Indications
- RVR control in a-fib/flutter, PSVT
Mechanism of Action
- Inhibits NaK pump
- Positive inotropy
- Negative chronotropy/dromotropy
- Indirect vagal stimulator
Adverse Drug Reactions
- GI: N/V, diarrhea, abd pain
- CV: Bradycardia, SA/AV block, ventr arrhythmias
Kinetics
- Onset of action = 1.5-4hr (IV)