Salvia toxicity
Revision as of 15:07, 25 September 2012 by Rossdonaldson1 (talk | contribs)
Background
- Historically used by shamans in rituals
- Active ingredient: Salvinorin A
- Kappa opiod receptor agonist and D2 agonist
- Hallucinogen
- Dissociative effects similar to ketamine
- Tea: 10 min onset, duration 30-90 min
- Smoked: 1-2 minute onset, tapers over 10-20 min
- Does not appear on typical tox screens
Clinical Features
- Uncontrollable laughter
- Intense hallucinations
- Diaphoresis
- Sensations of motion, lights, visions, overlapping realities
- Low toxicity, little hangover, low abuse potential
- Few reports of psychosis and suicide associated with use
Treatment
- Supportive
- Benzodiazepines as needed
- Most patients will have symptoms resolve prior to ED arrival given short duration of action
Source
David Burbulys, MD lecture 9/2012