Ewing sarcoma

Background

• Highly aggressive malignant bone or soft tissue tumor arising from cells of the neuroectoderm
• One-fourth of patients will have metastasis at the time of presentation
  • It is assumed that almost all patients have subclinical metastasis
• Presence and location of metastasis is the major prognostic factor for survival
• Metastasis is most frequently seen in bone (spine most common) and lungs
• Around 70 to 80 percent survival in those with non-metastatic disease
• More common in males