Zanamivir

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Administration

  • Type: Antiviral
  • Dosage Forms:
  • Routes of Administration: Inhalation
  • Common Trade Names:

Adult Dosing

  • Influenza: 10 mg inhaled orally BID x 5 days

Pediatric Dosing

  • >7 years old: 10mg inhaled orally BID

Special Populations

  • Pregnancy Rating: C
  • Lactation risk: Infant risk cannot be ruled out
  • Renal dosing: no adjustment
  • Hepatic dosing: no adjustment

Contraindications

  • Allergy to class/drug
  • Not recommended in patients with underlying respiratory disease

Adverse Reactions

Serious

  • Dysrhythmia
  • Seizure
  • Delirium, abnormal behavior
  • Bronchospasm
  • Oropharyngeal edema
  • Rash

Common

  • Cough, nasal symptoms, throat pain
  • Fever

Pharmacology

  • Half-life: 2.5-5.1h
  • Metabolism:
  • Excretion: Renal, fecal

Mechanism of Action

  • Inhibits neuroaminidase of influenza A and B, altering viral aggregation and release

Comments

See Also

References

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