Adenosine

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Adult Dosing

  • 6mg rapid IV bolus over 1-2s
    • If ineffective can try 12mg 2min later
      • If still ineffective can try another 12mg

Contraindications

  • 2nd, 3rd AV block
  • Sick sinus syndrome
  • Reentrant SVTs not involving AV node are not terminated
  • No effect on anterograde WPW

Indications

  • Conversion of reentrant PSVT to NSR

Mechanism of Action

  • Negative inotropic, dromotropic, chronotropic effects
  • Transient AV nodal block

Adverse Drug Rxns

  • Bronchoconstriction (responds to bronchodilators)
  • Bradyarrhythmia
  • Hypotension (if given too slowly)

Kinetics

Onset of action = 20-30s Duration of action = 60-90s

See Also

Antiarrhythmics

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