SNRI Toxicity

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Background

  • Inhibit reuptake of serotonin and norepinephrine (venlafaxine, duloxetine)
  • Although produce more symptoms in overdose compared to SSRIs, still extremely safe

Clinical Features

  • Sympathomimetic: tachycardia, hypertension, diaphoresis, tremor, mydriasis
  • Sedation
  • Seizure
  • ECG
    • Sinus tachycardia

Treatment

  1. GI decontamination
    1. Activatec charcoal x1

Disposition

  • Admit all symptomatic pts to a monitored bed
  • All pts require at least 6hr of observation

Source

  • Tintinalli
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