Baclofen toxicity

Background

• Indications include MS, muscle spasticity pain
• GABAb receptor agonist

Toxicity

• Adverse effects:
  • Drowziness, dizziness
  • N/V
  • Seizures, delirium, AMS
  • Bradycardia, hypotension, respiratory compromise

Management

• Diagnosis of exclusion
• Activated charcoal for recent ingestion
• Supportive care:
  • IV fluids, respiratory care
  • Benzodiazepines for seizures
• Hemodialysis for very severe toxicity

References

• Jung, M. “Baclofen Overdoses”. Maryland Poison Center, University of Maryland School of Pharmacy. www.mdpoison.com Accessed April 29th, 2014.
• Nicola Y Leung, Ian M Whyte, Geoffrey K Isbister Baclofen overdose: defining the spectrum of toxicity. Emerg Med Australas: 2006, 18(1);77-82