Ketofol

General

• Type: Sedative agents
• Dosage Forms:
• Common Trade Names:

Adult Dosing

• Starting dose: 0.5 mg/kg followed by another 0.5 mg/kg after 30-60 seconds
• Maintenance: 0.25 mg/kg as needed

Special Populations

• Pregnancy Rating:
• Lactation risk:
• Renal Dosing
  • Adult
  • Pediatric
• Hepatic Dosing
  • Adult
  • Pediatric

Contraindications

• Allergy to class/drug

Pharmacology

• Half-life:
• Metabolism:
• Excretion:
• Mechanism of Action:

Administration

• Ketamine comes in a 50 mg/mL concentration
• take a 10 mL saline flush and empty 2 mL and draw up 2 mL of ketamine
  • 100 mg of ketamine in flush

• Propofol comes in a standard 10 mg/mL concentration.
• fill a different 10 mL syringe with this you have 100 mg of propofol

• If you mix the two in a new 20 or 30 mL syringe you get 100 mg ketamine + 100 mg propofol = 200 mg total.
• Every one mL has 10 mg of ketofol.

Comments

• 2 definitions
  • 50% ketamine mixed with 50% propofol in same syringe
  • Pretreatment with 1/2 dose ketamine, followed by propofol