Midazolam: Difference between revisions
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==Adult Dosing== | ==Adult Dosing== | ||
*Anxiolysis/sedation: 1-2mg IV push | *Anxiolysis/sedation: | ||
**1-2mg IV push | |||
**0.07 to 0.08 mg/kg IM, usual dose 5 mg for 60 kg pt | |||
*ICU Sedation: | *ICU Sedation: | ||
**Load: 10-50mcg/kg IV infusion | **Load: 10-50mcg/kg IV infusion | ||
| Line 39: | Line 41: | ||
*Nausea/vomiting | *Nausea/vomiting | ||
==Pharmacology== | ==Pharmacology== | ||
*Peak effect: | |||
**IM: Children: 15 to 30 minutes; Adults: 30 to 60 minutes | |||
**IV: 5 to 7 minutes | |||
**Intranasal: 10 minutes | |||
*Half-life: 1.8-6.4 hr | *Half-life: 1.8-6.4 hr | ||
*Metabolism: Metabolized in liver by CYP3A4 to active metabolite alpha1-hydroxymidazolam | *Metabolism: Metabolized in liver by CYP3A4 to active metabolite alpha1-hydroxymidazolam | ||
Revision as of 16:24, 22 July 2016
See critical care quick reference for drug doses by weight.
General
- Type: Benzodiazepines
- Dosage Forms: IV
- Common Trade Names: Versed
Adult Dosing
- Anxiolysis/sedation:
- 1-2mg IV push
- 0.07 to 0.08 mg/kg IM, usual dose 5 mg for 60 kg pt
- ICU Sedation:
- Load: 10-50mcg/kg IV infusion
- Maintenance: 20-100 mcg/kg/hr infusion
- Use with standardized sedation protocol for titration
Pediatric Dosing
See critical care quick reference for drug doses by weight.
Special Populations
- Pregnancy Rating: D
- Maternal use shortly before delivery associated with floppy infant syndrome
- Lactation: Distributed in breast milk, use with caution
- Renal Dosing:
- Adult
- Pediatric
- Hepatic Dosing:
- Adult
- Pediatric
Contraindications
- Allergy to class/drug
Adverse Reactions
Serious
- Apnea
- Hypopnea
- Hypotension
- Delirium, when used for prolonged periods in ICU setting
Common
- Drowsiness
- Nausea/vomiting
Pharmacology
- Peak effect:
- IM: Children: 15 to 30 minutes; Adults: 30 to 60 minutes
- IV: 5 to 7 minutes
- Intranasal: 10 minutes
- Half-life: 1.8-6.4 hr
- Metabolism: Metabolized in liver by CYP3A4 to active metabolite alpha1-hydroxymidazolam
- Excretion: Renal
- Mechanism of Action: CNS depressant. Acts at GABA receptor to increase frequency of chloride channel opening, causing hyperpolarization and stabilization of neuronal membrane.
See Also
References
Micromedex