Ibuprofen: Difference between revisions
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*[[GI bleeding]] | *[[GI bleeding]] | ||
*ulceration and perforation of the stomach or intestines | *ulceration and perforation of the stomach or intestines | ||
* thromboycytopenia | *thromboycytopenia | ||
* agranulocytosis | *agranulocytosis | ||
* steven johnson syndrome | *steven johnson syndrome | ||
* nephrotoxicity | *nephrotoxicity | ||
===Common=== | ===Common=== | ||
* dyspepsia | *dyspepsia | ||
* nausea | *nausea | ||
* abdominal pain | *abdominal pain | ||
* constipation | *constipation | ||
* headache | *headache | ||
* dizziness | *dizziness | ||
* rash | *rash | ||
* fluid retention | *fluid retention | ||
* ecchymosis | *ecchymosis | ||
==Pharmacology== | ==Pharmacology== | ||
Revision as of 13:20, 7 July 2016
General
- Type: NSAID
- Dosage Forms:
- Common Trade Names: Advil; Motrin
Adult Dosing
- 600mg PO Q6hours
Pediatric Dosing
- 10 mg/kg PO Q6hours
- Max: 40 mg/kg/day
Special Populations
- Pregnancy Rating: C (1st-2nd trimester), D (3rd trimester)
- Lactation risk categories: L4; enters breast milk, decreases milk supply
- Renal Dosing
- Adult: no adjustment
- Pediatric: no adjustment
- Hepatic Dosing
- Adult: not defined
- Pediatric: not defined
Contraindications
- Allergy to class/drug
- Cardiovascular
- May cause an increased risk of serious cardiovascular thrombotic events, myocardial infarction, and stroke, which can be fatal
- Contraindicated for treatment of perioperative pain in the setting of coronary artery bypass graft (CABG) surgery
- Gastrointestinal risk
- Increased risk of serious gastrointestinal (GI) adverse events including bleeding, ulceration, and perforation of the stomach or intestines, which can be fatal
- Elderly patients are at greater risk for serious GI events.
- Increased risk of serious gastrointestinal (GI) adverse events including bleeding, ulceration, and perforation of the stomach or intestines, which can be fatal
Adverse Reactions
Serious
- GI bleeding
- ulceration and perforation of the stomach or intestines
- thromboycytopenia
- agranulocytosis
- steven johnson syndrome
- nephrotoxicity
Common
- dyspepsia
- nausea
- abdominal pain
- constipation
- headache
- dizziness
- rash
- fluid retention
- ecchymosis
Pharmacology
- Half-life: 1.8 - 2 hr
- Metabolism: liver
- Excretion: Urine
- Mechanism of Action: exact mechanism unknown; inhibits cyclooxygenase, reducing prostaglandin and thromboxane synthesis