Neomycin: Difference between revisions
Ostermayer (talk | contribs) (Text replacement - "Category:Drugs" to "Category:Pharmacology") |
Neil.m.young (talk | contribs) (Text replacement - "* " to "*") |
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==Adult Dosing== | ==Adult Dosing== | ||
Bowel Prep | Bowel Prep | ||
* 1000 mg PO at 1 pm, 2 pm and 11 pm the day before 8 am surgery. Alternative: 1000 mg po q1h x 4, then 1000 mg po q4h x 4 | *1000 mg PO at 1 pm, 2 pm and 11 pm the day before 8 am surgery. Alternative: 1000 mg po q1h x 4, then 1000 mg po q4h x 4 | ||
Hepatic Encephalopathy | Hepatic Encephalopathy | ||
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==Pediatric Dosing== | ==Pediatric Dosing== | ||
Bowel prep for 2-12 y/o | Bowel prep for 2-12 y/o | ||
* 25 mg/kg PO at 1 pm, 2 pm and 11 pm the day before 8 am surgery. Alternative: 90 mg/kg/day PO divided q4h x 2-3 days | *25 mg/kg PO at 1 pm, 2 pm and 11 pm the day before 8 am surgery. Alternative: 90 mg/kg/day PO divided q4h x 2-3 days | ||
==Special Populations== | ==Special Populations== | ||
*[[Drug Ratings in Pregnancy|Pregnancy Rating]]:D | *[[Drug Ratings in Pregnancy|Pregnancy Rating]]:D | ||
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==Contraindications== | ==Contraindications== | ||
*Allergy to class/drug | *Allergy to class/drug | ||
* GI obstruction | *GI obstruction | ||
==Adverse Reactions== | ==Adverse Reactions== | ||
===Serious=== | ===Serious=== | ||
Revision as of 15:30, 6 July 2016
Administration
- Type: Aminoglycoside; bowel preps
- Dosage Forms: 500
- Routes of Administration: PO
- Common Trade Names: Neo-Fradin
Adult Dosing
Bowel Prep
- 1000 mg PO at 1 pm, 2 pm and 11 pm the day before 8 am surgery. Alternative: 1000 mg po q1h x 4, then 1000 mg po q4h x 4
Hepatic Encephalopathy
- 1000-3000 mg po q6h x 5-6 days
Pediatric Dosing
Bowel prep for 2-12 y/o
- 25 mg/kg PO at 1 pm, 2 pm and 11 pm the day before 8 am surgery. Alternative: 90 mg/kg/day PO divided q4h x 2-3 days
Special Populations
- Pregnancy Rating:D
- Lactation risk: safety unknown
Renal Dosing
- Adult: not defined
- Pediatric:not defined
Hepatic Dosing
- Adult:not defined
- Pediatric:not defined
Contraindications
- Allergy to class/drug
- GI obstruction
Adverse Reactions
Serious
- nephrotoxicity
- ototoxicity
- neurotoxicity
- superinfection
Common
- nausea
- vomiting
- diarrhea
Pharmacology
- Half-life: 2-3 hour
- Metabolism: none
- Excretion: feces
Mechanism of Action
Bactericidal and amebicidal; binds to bacterial 30s ribosomal subunit, inhibiting protein synthesis, suppresses urease producing bacteria; reducing ammonia absorption from gut