Ondansteron: Difference between revisions
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Revision as of 03:40, 27 June 2016
General
- Type: anti-emetic
- Dosage Forms:4, 8
- Common Trade Names: Zofran
Adult Dosing
- Nausea/Vomiting: 4-8 mg q4h, max 24 mg a day
Pediatric Dosing
- Nausea/Vomiting: 0.1 mg/kg IV q4h max dose at once:4-8 mg, max 24 mg
- Gastroenteritis - Vomiting
- 8 to 15 kg:
- 2 mg orally disintegrating tablet dissolved orally as a single dose
- 15 to 30 kg:
- 4 mg orally disintegrating tablet dissolved orally as a single dose
- Greater than 30 kg:
- 8 mg orally disintegrating tablet dissolved orally as a single dose
- 8 to 15 kg:
Special Populations
- Pregnancy Rating:B
- Lactation:safety unknown
- Adult:
- Renal Dosing:not defined
- Hepatic Dosing: not defined
- Pediatric:
- Hepatic Dosing: not defined
- Renal Dosing:not defined
Contraindications
- Allergy to class/drug
- congenital long QT syndrome
Adverse Reactions
Serious
- bronchospasm
- steven-johnson syndrome
- QT prolongation
- torsades de pointes
- serotonin syndrome
- extrapyramidal SX
- blindness, transient
Common
- headache
- constipation
- fatigue
- hypoxia
- fever
- urinary retention
- agitation
Pharmacology
- Half-life: 4.6-5.7 hour
- Metabolism: liver
- Excretion: urine
- Mechanism of Action:selectively antagonizes serotonin 5-HT3 receptors