Antidotes: Difference between revisions
No edit summary |
No edit summary |
||
| Line 2: | Line 2: | ||
|- | |- | ||
| | | | ||
TOXIN | TOXIN | ||
| ANTIDOTE<br | | ANTIDOTE<br> | ||
|- | |- | ||
| [[Acetaminophen (Tylenol)|Acetaminophen]]<br | | [[Acetaminophen (Tylenol)|Acetaminophen]]<br> | ||
| N-acetylcysteine | | | ||
N-acetylcysteine | |||
150mg/kg IV load over 60min; followed by 50mg/kg IV over 4hr and then 100mg/kg IV over 16hr | |||
|- | |- | ||
| Antidepressants<br | | Antidepressants (TCA)<br> | ||
| | | | ||
Bicarbonate | |||
1-2mEq/kg IV bolus followed by 2mEq/kg/hr IV infusion | |||
|- | |- | ||
| Arsenic<br | | Arsenic<br> | ||
| Dimercaprol (BAL)<br | | Dimercaprol (BAL)<br> | ||
|- | |- | ||
| Benzodiazepines | | Benzodiazepines | ||
| Flumazenil | | | ||
Flumazenil | |||
Adult: 0.2mg IV | |||
Peds: 0.01mg/kg IV | |||
|- | |- | ||
| [[Beta-Blocker Toxicity |Beta blockers]]<br | | [[Beta-Blocker Toxicity|Beta blockers]]<br> | ||
| Glucagon | | | ||
Glucagon | |||
Adult: 3-10mg IV | |||
Peds: 50-150mcg/kg IV | |||
|- | |- | ||
| | | | ||
[[Calcium Channel Blocker Toxicity|Ca channel blockers]] | [[Calcium Channel Blocker Toxicity|Ca channel blockers]] | ||
| | |||
Calcium chloride 10% | |||
Adult: 10 mL IV | |||
Peds: 0.2-0.25 mL/kg IV | |||
|- | |- | ||
| | | | ||
Clonidine | Clonidine | ||
| | |||
Naloxone | |||
Adult: 0.4-2mg IV | |||
Peds: 0.01mg IV | |||
|- | |- | ||
| [[Cyanide]]<br | | [[Cyanide]]<br> | ||
| | | | ||
Kit- Hydroxycobalamin, Sodium nitrite, Sodium thiosulfate | Kit- Hydroxycobalamin, Sodium nitrite, Sodium thiosulfate | ||
|- | |- | ||
| [[Digoxin Toxicity|Digoxin]]<br | | [[Digoxin Toxicity|Digoxin]]<br> | ||
| [[Dig Immune Fab]]<br | | [[Dig Immune Fab]]<br> | ||
|- | |- | ||
| [[Ethylene Glycol Poisoning|Ethylene glycol]]<br | | [[Ethylene Glycol Poisoning|Ethylene glycol]]<br> | ||
| Fomepizole | | | ||
Fomepizole | |||
15mi/kg IV; then 10mg/kg q12h | |||
|- | |- | ||
| Fluoride | | Fluoride | ||
| Calcium | | Calcium | ||
|- | |- | ||
| [[Heparin (Unfractionated)|Heparin]]<br | | [[Heparin (Unfractionated)|Heparin]]<br> | ||
| Protamine | | | ||
Protamine | |||
Adult: 25-50mg IV (empiric dose) | |||
Peds: 0.6mg/kg IV (empiric dose) | |||
|- | |- | ||
| [[Iron (Fe)|Iron]]<br | | [[Iron (Fe)|Iron]]<br> | ||
| Deferoxamine<br | | Deferoxamine<br> | ||
|- | |- | ||
| Isoniazid (INH)<br | | Isoniazid (INH)<br> | ||
| Pyridoxine | | | ||
Pyridoxine | |||
Adult: 5gm IV | |||
Peds: 70mg/kg IV (max 5gm) | |||
|- | |- | ||
| Lead<br | | Lead<br> | ||
| EDTA, succimer<br | | EDTA, succimer<br> | ||
|- | |- | ||
| Mercury<br | | Mercury<br> | ||
| Dimercaprol (BAL)<br | | Dimercaprol (BAL)<br> | ||
|- | |- | ||
| Methanol<br | | Methanol<br> | ||
| Fomepizole<br/> | | Fomepizole<br>15mi/kg IV; then 10mg/kg q12h<br> | ||
|- | |- | ||
| Methemoglobin<br | | Methemoglobin<br> | ||
| Methylene blue<br | | Methylene blue<br> | ||
|- | |- | ||
| [[Opiod Overdose|Opiods]]<br | | [[Opiod Overdose|Opiods]]<br> | ||
| Nalaxone<br | | Nalaxone<br> | ||
|- | |- | ||
| [[Organophosphates]]<br | | [[Organophosphates]]<br> | ||
| Atropine+pralidoxime<br | | Atropine+pralidoxime<br> | ||
|- | |- | ||
| Sulfonylurea | | Sulfonylurea | ||
| Octreotide | | | ||
Octreotide | |||
Adult: 50–100mcg SC q6hr | |||
Peds: 1mcg/kg SC q6hr | |||
|- | |- | ||
| Valproate<br | | Valproate<br> | ||
| Carnitine<br | | Carnitine<br> | ||
|- | |- | ||
| [[Warfarin (Coumadin) Reversal|Warfarin]]<br | | [[Warfarin (Coumadin) Reversal|Warfarin]]<br> | ||
| Vit K, FFP<br | | Vit K, FFP<br> | ||
|} | |} | ||
==Source== | == Source == | ||
9/09 PANI (Adapted from Donaldson, Mistry, Pharmacopia) | 9/09 PANI (Adapted from Donaldson, Mistry, Pharmacopia) | ||
[[Category:Tox]] | [[Category:Tox]] | ||
Revision as of 07:18, 20 December 2011
|
TOXIN |
ANTIDOTE |
| Acetaminophen |
N-acetylcysteine 150mg/kg IV load over 60min; followed by 50mg/kg IV over 4hr and then 100mg/kg IV over 16hr |
| Antidepressants (TCA) |
Bicarbonate 1-2mEq/kg IV bolus followed by 2mEq/kg/hr IV infusion |
| Arsenic |
Dimercaprol (BAL) |
| Benzodiazepines |
Flumazenil Adult: 0.2mg IV Peds: 0.01mg/kg IV |
| Beta blockers |
Glucagon Adult: 3-10mg IV Peds: 50-150mcg/kg IV |
|
Calcium chloride 10% Adult: 10 mL IV Peds: 0.2-0.25 mL/kg IV | |
|
Clonidine |
Naloxone Adult: 0.4-2mg IV Peds: 0.01mg IV |
| Cyanide |
Kit- Hydroxycobalamin, Sodium nitrite, Sodium thiosulfate |
| Digoxin |
Dig Immune Fab |
| Ethylene glycol |
Fomepizole 15mi/kg IV; then 10mg/kg q12h |
| Fluoride | Calcium |
| Heparin |
Protamine Adult: 25-50mg IV (empiric dose) Peds: 0.6mg/kg IV (empiric dose) |
| Iron |
Deferoxamine |
| Isoniazid (INH) |
Pyridoxine Adult: 5gm IV Peds: 70mg/kg IV (max 5gm) |
| Lead |
EDTA, succimer |
| Mercury |
Dimercaprol (BAL) |
| Methanol |
Fomepizole 15mi/kg IV; then 10mg/kg q12h |
| Methemoglobin |
Methylene blue |
| Opiods |
Nalaxone |
| Organophosphates |
Atropine+pralidoxime |
| Sulfonylurea |
Octreotide Adult: 50–100mcg SC q6hr Peds: 1mcg/kg SC q6hr |
| Valproate |
Carnitine |
| Warfarin |
Vit K, FFP |
Source
9/09 PANI (Adapted from Donaldson, Mistry, Pharmacopia)