Template:Serotonin syndrome vs neuroleptic malignant syndrome: Difference between revisions

Revision as of 19:53, 26 February 2016

History of a new serotonergic drug or a dose increase of a serotonergic drug are helpful
Serotonin syndrome is usually much more acute in onset than NMS which may develop over days or weeks
Presence of ‘lead pipe’ rigidity is typical of NMS, while patients with serotonin syndrome manifest tremor and hyperreflexia
Elevations in CK, LFTs, and WBC, coupled with a low iron level, distinguishes NMS from serotonin syndrome among patients taking neuroleptic and serotonin agonist medications simultaneously

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-===[[Serotonin syndrome]] vs [[neuroleptic malignant syndrome]]===
+===[[Serotonin syndrome]] vs [[Neuroleptic malignant syndrome]]===
-*Differentiation between the [[serotonin syndrome]] and [[NMS]] can be challenging. History of a new serotonergic drug or a dose increase of a serotonergic drug are helpful. [[serotonin syndrome]] is usually much more acute in onset than NMS which may develop over days or weeks. On physical exam the presence of ‘lead pipe’ rigidity is typical of NMS, while patients with [[serotonin syndrome]] manifest tremor and hyperreflexia.
+*History of a new serotonergic drug or a dose increase of a serotonergic drug are helpful
-*Elevations in creatine kinase, liver function tests (lactate dehydrogenase, aspartate transaminase), and white blood cell count, coupled with a low serum iron level, distinguishes NMS from [[serotonin syndrome]] among patients taking neuroleptic and serotonin agonist medications simultaneously.
+*Serotonin syndrome is usually much more acute in onset than NMS which may develop over days or weeks
+*Presence of ‘lead pipe’ rigidity is typical of NMS, while patients with serotonin syndrome manifest tremor and hyperreflexia
+*Elevations in CK, LFTs, and WBC, coupled with a low iron level, distinguishes NMS from serotonin syndrome among patients taking neuroleptic and serotonin agonist medications simultaneously