Template:Amiodarone adverse effects: Difference between revisions

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**More commonly, the cytotoxic effects of amiodarone destroy thyroid cells, resulting in a release of preformed hormone.
**More commonly, the cytotoxic effects of amiodarone destroy thyroid cells, resulting in a release of preformed hormone.
*[[Amiodarone Pulmonary Toxicity]]
*[[Amiodarone Pulmonary Toxicity]]
*Hyperpigmentation rash[[File:Amiodarone_hyperpigmentation.jpg|thumbnail]]

Revision as of 20:00, 18 February 2016

  • Bradycardia
  • Hypotension with older solvent-based formulation. Uncommon with newer aqueous formulation.
  • Prolonged QT
  • Thyrotoxicosis[1]
    • Between 5-20% of patients treated with amiodarone have thyrotoxicosis (higher in areas of iodine deficiency)
  • Iodine-induced hyperthyroidism
    • It is thought that the iodine load may unmask hyperthyroidism in patients with multinodular goiter and subclinical Graves’ disease
  • Drug-induced destructive thyroiditis
    • More commonly, the cytotoxic effects of amiodarone destroy thyroid cells, resulting in a release of preformed hormone.
  • Amiodarone Pulmonary Toxicity
  • Hyperpigmentation rash
    Amiodarone hyperpigmentation.jpg
  1. Rosen's 8th Edition