Mycophenolate mofetil: Difference between revisions
(adult dosing edits) |
(adult renal dosing edits) |
||
| Line 29: | Line 29: | ||
===Renal Dosing=== | ===Renal Dosing=== | ||
*Adult: | *Adult: | ||
**kidney transplant pts, delayed graft fxn immediate postop: no adjustment | |||
**kidney transplant pts, outside immediate post-transplant period:CrCl <25: max 1 g bid; HD/PD: no supplement | |||
**heart or liver transplant pts: CrCl <25: weigh risk/benefit; HD/PD: not defined | |||
*Pediatric: | *Pediatric: | ||
===Hepatic Dosing=== | ===Hepatic Dosing=== | ||
*Adult: | *Adult: | ||
Revision as of 22:34, 10 February 2016
Administration
- Type: Immunosuppressant
- Dosage Forms: 250,500; 200 mg/mL; IV
- Routes of Administration: PO, IV
- Common Trade Names: CellCept
Adult Dosing
Kidney transplant rejection prophylaxis
- 1 g PO/IV bid
- Start: IV w/ in 24h post transplant, continue up to 14 days, switch to PO ASAP; Info: give on empty stomach; stable pts may take w/ food
Heart transplant rejection prophylaxis
- 1.5 g PO/IV bid
- Start: IV w/ in 24h post transplant, continue up to 14 days, switch to PO ASAP; Info: give on empty stomach
Liver transplant rejection prophylaxis
- 1.5 g PO bid or 1 g IV bid
- Info: start IV w/ in 24h post transplant, continue up to 14 days, switch to PO ASAP; Info: give on empty stomach
Lupus nephritis
- 1 g PO bid
- Info: use w/ prednisone, consider decease dose 50% after 6mo tx
Pediatric Dosing
Special Populations
Renal Dosing
- Adult:
- kidney transplant pts, delayed graft fxn immediate postop: no adjustment
- kidney transplant pts, outside immediate post-transplant period:CrCl <25: max 1 g bid; HD/PD: no supplement
- heart or liver transplant pts: CrCl <25: weigh risk/benefit; HD/PD: not defined
- Pediatric:
Hepatic Dosing
- Adult:
- Pediatric:
Contraindications
- Allergy to class/drug
Adverse Reactions
Serious
Common
Pharmacology
- Half-life:
- Metabolism:
- Excretion: