Azathioprine: Difference between revisions
(administration edits) |
(adult dosing edits) |
||
| Line 6: | Line 6: | ||
==Adult Dosing== | ==Adult Dosing== | ||
===Kidney transplant rejection prophylaxis=== | |||
*1-3 mg/kg PO qd | |||
*Start: 3-5 mg/kg PO x1 up to 3 days before transplant; Info: transplant protocols may vary | |||
===Rheumatoid arthritis, severe=== | |||
*1-2.5 mg/kg/day PO divided qd-bid | |||
*Start: 1 mg/kg/day PO divided qd-bid; Max: 2.5 mg/kg/day; Info: after 6-8wk may incr. 0.5 mg/kg/day q4wk | |||
===Crohns Disease=== | |||
*100-250 mg PO qd | |||
*Start: 50 mg PO qd; Max: 2.5 mg/kg/day; Info: for induction or remission maintenance and fistulizing disease, steroid-sparing effects | |||
===Ulcerative colitis=== | |||
*100-250 mg PO qd | |||
*Start: 50 mg PO qd; Max: 2.5 mg/kg/day; Info: for induction or remission maintenance, steroid-sparing effects | |||
==Pediatric Dosing== | ==Pediatric Dosing== | ||
Revision as of 02:37, 9 February 2016
Administration
- Type: immunosuppressant
- Dosage Forms: 50
- Routes of Administration: PO (IV form unavailable in US)
- Common Trade Names: Azasan, Imuran
Adult Dosing
Kidney transplant rejection prophylaxis
- 1-3 mg/kg PO qd
- Start: 3-5 mg/kg PO x1 up to 3 days before transplant; Info: transplant protocols may vary
Rheumatoid arthritis, severe
- 1-2.5 mg/kg/day PO divided qd-bid
- Start: 1 mg/kg/day PO divided qd-bid; Max: 2.5 mg/kg/day; Info: after 6-8wk may incr. 0.5 mg/kg/day q4wk
Crohns Disease
- 100-250 mg PO qd
- Start: 50 mg PO qd; Max: 2.5 mg/kg/day; Info: for induction or remission maintenance and fistulizing disease, steroid-sparing effects
Ulcerative colitis
- 100-250 mg PO qd
- Start: 50 mg PO qd; Max: 2.5 mg/kg/day; Info: for induction or remission maintenance, steroid-sparing effects
Pediatric Dosing
Special Populations
Renal Dosing
- Adult:
- Pediatric:
Hepatic Dosing
- Adult:
- Pediatric:
Contraindications
- Allergy to class/drug
Adverse Reactions
Serious
Common
Pharmacology
- Half-life:
- Metabolism:
- Excretion: