Succinylcholine: Difference between revisions
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==Pharmacology== | ==Pharmacology== | ||
*Onset: | *Onset: IV: 30-60 seconds; IM: 2-3 minutes | ||
*Metabolism: | *Metabolism: Plasma pseudocholinesterase hydrolysis | ||
*Excretion: | *Excretion: Urine | ||
*Mechanism of Action: | *Mechanism of Action: Depolarization of the myoneural junction motor endplate | ||
*Duration of Action: | *Duration of Action: IV: 4-6 minutes; IM 10-30 minutes | ||
==See Also== | ==See Also== | ||
Revision as of 04:31, 6 October 2015
See critical care quick reference for drug doses by weight.
General
- Type: Neuromuscular blocker
- Dosage Forms: IV or IM
- Common Trade Names: Anectine; Quelicin; Quelicin-1000
Adult Dosing
- 1.5 mg/kg IV
- 4 mg/kg IM (in extremis)
Pediatric Dosing
See critical care quick reference for drug doses by weight.
Special Populations
- Pregnancy Rating: C
- Lactation: Unknown if compound is excreted in breast milk
- Renal Dosing
- Adult
- Pediatric
- Hepatic Dosing
- Adult
- Pediatric
Contraindications
- Hyperkalemia
- Preexisting hyperkalemia
- Burns >5d old
- Crush injury >5d old
- Severe infection >5d old
- Neuromuscular diseases (e.g. Myasthenia Gravis), myopathies
- History of Malignant Hyperthermia
- Allergy to class/drug
Adverse Reactions
Serious
- Fatal hyperkalemia
- Malignant hyperthermia
- Masseter spasm
Common
Pharmacology
- Onset: IV: 30-60 seconds; IM: 2-3 minutes
- Metabolism: Plasma pseudocholinesterase hydrolysis
- Excretion: Urine
- Mechanism of Action: Depolarization of the myoneural junction motor endplate
- Duration of Action: IV: 4-6 minutes; IM 10-30 minutes
See Also
Sources
- Levitan, R. Annals of EM. Vol 45, Issue 2. Safety of succinylcholine in myasthenia gravis.