Myelophthistic anemia: Difference between revisions
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*Admit for bone marrow biopsy and treatment of underlying disease | *Admit for bone marrow biopsy and treatment of underlying disease | ||
==See Also== | ==See Also== | ||
*[Anemia] | *[[Anemia]] | ||
*[Transfusions] | *[[Transfusions]] | ||
==External Links== | ==External Links== | ||
==References== | ==References== | ||
<references/> | <references/> | ||
Revision as of 17:57, 3 August 2015
Background
- Form of normocytic anemia
- Associated with infiltrative disorder or bone marrow in the setting of malignancy--leukemia, lymphoma, granuloma
Clinical Features
- Anemia in patient with h/o malignancy
- Pale skin
- Tachycardia/hypotension in severe cases
- Hepatosplenomegaly as sign of extra medullary hematopoiesis
Differential Diagnosis
- Aplastic anemia
- Myelofibrosis
- Acute blood loss anemia
- Bone marrow suppression
- Anemia of chronic disease
- Hemolytic anemia
Diagnosis
- Requires bone marrow biopsy
- Labs show normocytic anemia with decreased reticulocyte count
- Exam with signs of extra medullary hematopoiesis
- Index of suspicion in setting of malignancy
Management
- Identify anemia as emergent or non-emergent
- Evaluate for superimposed etiologies of anemia (Ie acute blood loss) and target treatment in the ED
- If emergent anemia get IV access, transfuse for signs of end organ damage--AMS, hypotension, chest pain, shortness of breath, decreased UOP
- Will need treatment of underlying malignancy to allow marrow recovery while supporting hemodynamics
Disposition
- Admit for bone marrow biopsy and treatment of underlying disease