Baclofen toxicity: Difference between revisions
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*Most excretion is renal | *Most excretion is renal | ||
== | ==Clinical Features== | ||
*N/V | *N/V | ||
*Drowziness, dizziness | *Drowziness, dizziness | ||
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*Bradycardia, hypotension OR HTN, respiratory compromise | *Bradycardia, hypotension OR HTN, respiratory compromise | ||
*Hypothermia | *Hypothermia | ||
==Differential Diagnosis== | |||
==Diagnosis== | |||
==Management== | ==Management== | ||
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**Benzodiazepines for seizures | **Benzodiazepines for seizures | ||
*Hemodialysis for very severe toxicity | *Hemodialysis for very severe toxicity | ||
==Disposition== | |||
==See Also== | |||
==References== | ==References== | ||
<References/> | |||
*Jung, M. “Baclofen Overdoses”. Maryland Poison Center, University of Maryland School of Pharmacy. www.mdpoison.com Accessed April 29th, 2014. | *Jung, M. “Baclofen Overdoses”. Maryland Poison Center, University of Maryland School of Pharmacy. www.mdpoison.com Accessed April 29th, 2014. | ||
*Nicola Y Leung, Ian M Whyte, Geoffrey K Isbister Baclofen overdose: defining the spectrum of toxicity. Emerg Med Australas: 2006, 18(1);77-82 | *Nicola Y Leung, Ian M Whyte, Geoffrey K Isbister Baclofen overdose: defining the spectrum of toxicity. Emerg Med Australas: 2006, 18(1);77-82 | ||
[Category:Tox] | |||
Revision as of 03:09, 17 July 2015
Background
- Indications include MS, muscle spasticity pain
- GABAb receptor agonist
- Most excretion is renal
Clinical Features
- N/V
- Drowziness, dizziness
- Seizures, delirium, AMS, coma
- Bradycardia, hypotension OR HTN, respiratory compromise
- Hypothermia
Differential Diagnosis
Diagnosis
Management
- Diagnosis of exclusion
- Activated charcoal for recent ingestion
- Supportive care:
- IV fluids, respiratory care
- Vasopressors for persistent hypotension
- Benzodiazepines for seizures
- Hemodialysis for very severe toxicity
Disposition
See Also
References
- Jung, M. “Baclofen Overdoses”. Maryland Poison Center, University of Maryland School of Pharmacy. www.mdpoison.com Accessed April 29th, 2014.
- Nicola Y Leung, Ian M Whyte, Geoffrey K Isbister Baclofen overdose: defining the spectrum of toxicity. Emerg Med Australas: 2006, 18(1);77-82
[Category:Tox]