Vitamin K: Difference between revisions
No edit summary |
(Added neonatal deficiency, mech of action initial content.) |
||
| Line 1: | Line 1: | ||
==General== | ==General== | ||
*Type: | *Type: | ||
Revision as of 16:40, 29 June 2015
General
- Type:
- Dosage Forms:
- Common Trade Names:
Adult Dosing
Pediatric Dosing
- Neonatal deficiency: May underlie hemorrhagic disease of the newborn. 1mg vitamin K SC for avoidance of anaphylaxis (IV), hematoma (IM). FFP for serious cases.
Special Populations
- Pregnancy Rating:
- Lactation risk:
- Renal Dosing
- Adult
- Pediatric
- Hepatic Dosing
- Adult
- Pediatric
Contraindications
- Allergy to class/drug
Adverse Reactions
Serious
Common
Pharmacology
- Half-life:
- Metabolism:
- Excretion:
- Mechanism of Action: Used by liver for synthesis of some coagulation factors (II,VII,IX,X,C,S). Timing in the synthesis of these factors impacts reversal of elevated INR (~4 hours: F-VII, ~24 hours: F-II). [Various: Lange Clinical. Tintinalli]