Hydrocortisone topical: Difference between revisions
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==Contraindications== | ==Contraindications== | ||
*Allergy to class/drug | *Allergy to class/drug | ||
*caution if skin infection | |||
*caution in pediatric pts | |||
==Adverse Reactions== | ==Adverse Reactions== | ||
Revision as of 21:08, 26 June 2015
General
- Type: Topical steroid
- Dosage Forms: 0.5%, 1%, 2.5% crm, lotion, oint
- Common Trade Names:
Adult Dosing
dermatoses, steroid-responsive: apply bid-qid
Pediatric Dosing
dermatoses, steroid-responsive: apply bid-qid
Special Populations
- Pregnancy Rating: C
- Lactation: Probably safe
- Renal Dosing
- Adult: none
- Pediatric: none
- Hepatic Dosing
- Adult: none
- Pediatric: none
Contraindications
- Allergy to class/drug
- caution if skin infection
- caution in pediatric pts
Adverse Reactions
Serious
- HPA axis suppresion
- Cushing syndrome
- hyperglycemia
- intracranial HTN (peds pts)
Common
- burning
- pruritus
- irritation
- dryness
- folliculitis
- hypertrichosis
- acneiform dermatitis
- hypopigmentation
- perioral dermatitis
- allergic contact dermatitis
- maceration
- secondary infection
- skin atrophy
- striae
- miliaria
Pharmacology
- Half-life: 8-12h
- Metabolism: liver primarily; CYP450
- Excretion: urine
- Mechanism of Action: exact mechanim of anti-inflammatory action unknown; inhibits multiple inflammatory cytokines; produces multiple gluocorticoid and mineralocorticoid effects