Ricin: Difference between revisions

Revision as of 02:00, 10 June 2015

Background

Found in castor beans from the plant Ricinus communis
- A residual product of the production of castor oil (if properly prepared, does not contain the toxin)

Clinical Features

Depends on type of exposure (parenteral, inhaled, or ingested)
First symptoms occcur 3-12 hours after exposure
Multiorgan failure occurred with a prominently elevated white blood cell count.
acute lung injury
Pulmonary edema may develop one to 3 days after exposure,

- fever, cough, shortness of breath, and nausea.

symptoms and time to death were also dose

related and associated with alveolar flooding, fibropurulent pneumonia, and necrotizing tracheitis.

Death 36-48 hours after exposure

Differential Diagnosis

Diagnosis

Chest x-ray = bilateral infiltrates

Management

Disposition

External Links

References

Lutwick LI,Gradon J, Zellen J: Category B Biotoxins. In Lutwick LI, Lutwick SM (eds), Beyond Anthrax: Bioterror - The Weaponization of Infectious Diseases. Springer-Humana, New York, 2009, New York, pp. 181-206:

Authors:

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 ==Background==
-*found in castor beans from the plant _Ricinus communis
+*Found in castor beans from the plant ''Ricinus communis''
-**a residual product of the production of castor oil (if properly prepared, does not contain the toxin)
+**A residual product of the production of castor oil (if properly prepared, does not contain the toxin)
-==Clinical Presentation==
+==Clinical Features==
-*depends on whether the exposure is parenteral, inhaled, or ingested.
+*Depends on type of exposure (parenteral, inhaled, or ingested)
-*The 1st symptoms of toxicity generally occur 6-12 hours after exposure but can occur as early as 3 hours.
+*First symptoms occcur 3-12 hours after exposure
-* multiorgan failure occurred with a prominently elevated white blood cell count.
+*Multiorgan failure occurred with a prominently elevated white blood cell count.
 *acute lung injury
 *Pulmonary edema may develop one to 3 days after exposure,
-*sublethal and accidental exposures were said
-to have occurred and were manifest 4-8 hours after exposure
 **fever, cough, shortness of breath, and nausea.
-*Chest x-ray would be expected to show bilateral infiltrates.
 *symptoms and time to death were also dose
 related and associated with alveolar flooding, fibropurulent
-pneumonia, and necrotizing tracheitis. Death occurred 36 to 48 hours
+pneumonia, and necrotizing tracheitis.
-after challenge following a 8-24 hour preclinical period.
+*Death 36-48 hours after exposure
-==Source==
+==Differential Diagnosis==
-Lutwick LI,Gradon J, Zellen J: Category B Biotoxins. In Lutwick LI, Lutwick SM (eds), Beyond Anthrax: Bioterror - The Weaponization of Infectious Diseases. Springer-Humana, New York, 2009, New York, pp. 181-206:
+==Diagnosis==
+*Chest x-ray = bilateral infiltrates
+==Management==
+==Disposition==
+==See Also==
+==External Links==
+==References==
+<references/>
+*Lutwick LI,Gradon J, Zellen J: Category B Biotoxins. In Lutwick LI, Lutwick SM (eds), Beyond Anthrax: Bioterror - The Weaponization of Infectious Diseases. Springer-Humana, New York, 2009, New York, pp. 181-206:
 [[Category:Tox]]
 [[Category:EMS]]