Cyclobenzaprine: Difference between revisions
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*[[Drug Ratings in Pregnancy|Pregnancy Rating]]: B | *[[Drug Ratings in Pregnancy|Pregnancy Rating]]: B | ||
*[[Lactation risk categories|Lactation risk]]: infant risk cannot be ruled out | *[[Lactation risk categories|Lactation risk]]: infant risk cannot be ruled out | ||
*'''[[High-risk geriatric medication]]!''' | |||
===Renal Dosing=== | ===Renal Dosing=== | ||
Latest revision as of 23:28, 20 May 2026
Administration
- Type: Muscle relaxant
- Dosage Forms:
- Routes of Administration: Oral
- Common Trade Names: Flexeril
Adult Dosing
- 5-10mg PO 1-3 times per day
Pediatric Dosing
- >15 y/o
- 5-10 mg TID
Special Populations
- Pregnancy Rating: B
- Lactation risk: infant risk cannot be ruled out
- High-risk geriatric medication!
Renal Dosing
- Adult:
- Pediatric:
Hepatic Dosing
- Adult: Titrate slowly
- Pediatric:
Contraindications
- Allergy to class/drug
- MAOI use, concomitantly or within 14 days
- Heart block or other serious arrhythmias, CHF
Adverse Reactions
Serious
- Neuroleptic malignant syndrome
- Serotonin syndrome
- Stroke
- Dysrhythmias, heart block
- Bone marrow depression
- Hepatitis
Common
- Somnolence, dizziness
- Nausea, constipation
Pharmacology
- Half-life: ~18h for immediate release, 32h for extended release
- Metabolism: hepatic
- Excretion: Urine
Mechanism of Action
- Acts on CNS to reduce tonic somatic motor activity
Toxicity
- Similar to Tricyclic antidepressant toxicity, molecular structure similar and urine testing can be positive for TCAs
- Can have anticholinergic toxidrome in overdose