Loratadine

Administration

• Type: H1 antagonists (second generation)
• Dosage Forms: Tablets (chewable or orally disintegrating tablets [ODTs]), liquid-filled capsules, or a syrup (1 mg/mL solution)
• Routes of Administration: Oral
• Common Trade Names: Claritin

Adult Dosing

Allergic rhinitis

• 10 mg PO once daily, OR
• 5 mg twice daily
• Do not exceed 10 mg in 24 hours

Urticaria

• 10 mg PO once daily
  • Some patients may benefit from higher doses. Clinicians should weigh the risks against the benefits.

Pediatric Dosing

Allergic rhinitis

• Children aged ≥6 years old
  • 10 mg PO once daily, OR
• Children aged 2 to 5
  • 5 mg PO once daily
  • Do not exceed 10 mg in 24 hours
  • The ODT formulation is not recommended for younger children.

Urticaria

• Children aged ≥6 years old
  • 10 mg PO once daily
    • Some patients may benefit from higher doses. Clinicians should weigh the risks against the benefits.

Special Populations

Pregnancy Rating

• Should be safe for use during pregnancy; the risk of harm to the fetus is not expected based on limited human data;

Renal Dosing

• Adult:
• Pediatric:

Hepatic Dosing

• Adult:
• Pediatric:

Contraindications

• Allergy to class/drug

Pharmacology

• Half-life:
• Metabolism:
• Excretion: