Deferoxamine: Difference between revisions
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*Chelates iron and creates a water-soluble compound ferrioxamine that is renally excreted and can be dialyzed.<ref name="ironoverview"></ref> | *Chelates iron and creates a water-soluble compound ferrioxamine that is renally excreted and can be dialyzed.<ref name="ironoverview">Perrone J. Iron. In: Nelson LS, Howland MA, Lewin NA, et al., eds. Goldfrank's Toxicologic Emergencies. 11th ed. New York, NY: McGraw-Hill; 2019.</ref> | ||
Latest revision as of 01:01, 21 March 2026
General
- Type: Antidote
- Dosage Forms:
- Routes of Administration: IV, IM
- Common Trade Names: Desferal
Adult Dosing
Iron toxicity
- 1000mg IV; start at 5mg/kg/hr, increase up to 15mg/kg/hr as tolerated for up to 24hrs
- Subsequent doses are 500mg increments guided by clinical status of patient / urine color
- Recommended amount during first 24hr is 360mg/kg not to exceed 6g.
Pediatric Dosing
Iron toxicity
- 15 mg/kg/h IV
- Prolonged use >24-48 hours may increase risk of ARDS
- 100mg deferoxamine chelates 9mg free iron
Special Populations
- Pregnancy Rating:
- Lactation risk:
- Renal Dosing
- Adult: Contraindicated in severe impairment or anuria.
- Pediatric: Contraindicated in severe impairment or anuria
- Hepatic Dosing
- Adult: Not defined
- Pediatric: Not defined
Indications
- Systemic toxicity and iron level > 350 mcg/dL
- Metabolic acidosis
- Progressive symptoms
- Serum iron level >500 mcg/dL
Contraindications
- Allergy to class/drug
- Renal failure patients not on hemodialysis
Adverse Reactions
- Hypotension (pre-existing hypotension is NOT a contraindication to therapy)
- ARDS
- Yersinia enterocolitica sepsis[1]
- Can see "vin rose" colored urine from chelated iron extretion
- Cataracts with long term use
- Angioedema
- Flushing, urticaria, fever, myalgia, nausea, vomiting
Pharmacology
- Half-life: 6h
- Metabolism: Plasma
- Excretion: Urine, bile/feces
- Mechanism of Action:
Comments
- Chelates iron and creates a water-soluble compound ferrioxamine that is renally excreted and can be dialyzed.[2]
Indications by Condition
The following table is automatically generated from disease/condition pages across WikEM.
| Indication | Dose | Context | Route | Population |
|---|---|---|---|---|
| Iron toxicity | 5-15 mg/kg/hr IV infusion | Iron chelation | IV drip | Adult |
| Iron toxicity | 5-15 mg/kg/hr IV infusion | Iron chelation | IV drip | Pediatric |
See Also
References
- ↑ Mazzoleni G. et al. Yersinia enterocolitica infection with ileal perforation associated with iron overload and deferoxamine therapy. Dig Dis Sci 1991; 36:1154-1160.
- ↑ Perrone J. Iron. In: Nelson LS, Howland MA, Lewin NA, et al., eds. Goldfrank's Toxicologic Emergencies. 11th ed. New York, NY: McGraw-Hill; 2019.