Icatibant: Difference between revisions
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RESULTS- significantly shorter (8 hrs vs 27.1 hrs) in icatibant group. | RESULTS- significantly shorter (8 hrs vs 27.1 hrs) in icatibant group. | ||
*Cost according to Goodrx= $9,000/dose (on 8/7/2015) | *Cost according to Goodrx= $9,000/dose (on 8/7/2015) | ||
==Indications by Condition== | |||
''The following table is automatically generated from disease/condition pages across WikEM.'' | |||
{{#ask:[[Has DrugName::Icatibant]] | |||
|?Has Indication=Indication | |||
|?Has Dose=Dose | |||
|?Has Context=Context | |||
|?Has Route=Route | |||
|?Has Population=Population | |||
|format=broadtable | |||
|headers=plain | |||
|link=subject | |||
|sort=Has Indication | |||
|limit=50 | |||
}} | |||
==See Also== | ==See Also== | ||
Revision as of 16:44, 20 March 2026
General
- Type: Bradykinin receptor antagonist
- Dosage Forms: 30mg
- Routes of Administration: Subcutaneous
- Common Trade Names: Firazyr
Adult Dosing
Hereditary angioedema
- 30mg subcutaneous x 1
- May repeat q6h if inadequate response/symptoms recur
- Max 90mg/24 hours
Pediatric Dosing
not available (8/2015)
Special Populations
- Pregnancy Rating: C
- Lactation risk: safety unknown
- Renal Dosing
- Hepatic Dosing
Contraindications
- Allergy to class/drug
Adverse Reactions
Serious
- Caution if acute MI
- Caution if unstable angina
- Caution if recent stroke
Common
- Injection site reaction
- Dizziness
- Fever
- Increased LFTs
Pharmacology
- Half-life: 1.4h
- Metabolism: Proteolytic degradation
- Excretion: Urine 10% unchanged
- Mechanism of Action: selectively antagonizes bradykinin B2 receptor
Comments
- NEJM article 1/2015 randomized 27 people with ACEi induced angioedema to icatibant vs std therapy (Prednisone 500mg + Clemastine 2mg) looking at time to resolution.
RESULTS- significantly shorter (8 hrs vs 27.1 hrs) in icatibant group.
- Cost according to Goodrx= $9,000/dose (on 8/7/2015)
Indications by Condition
The following table is automatically generated from disease/condition pages across WikEM.
| Indication | Dose | Context | Route | Population | |
|---|---|---|---|---|---|
| Angioedema#Icatibant Bradykinin B2 receptor antagonist (HAE/ACE-I angioedema) Adult | Angioedema | 30 mg SC | Bradykinin B2 receptor antagonist (HAE/ACE-I angioedema) | SC | Adult |