Nitroglycerin: Difference between revisions
(contraindication) |
(reactions) |
||
| Line 31: | Line 31: | ||
==Adverse Reactions== | ==Adverse Reactions== | ||
===Serious=== | ===Serious=== | ||
*hypotension | |||
*bradycardia | |||
*methemoglobinemia | |||
===Common=== | ===Common=== | ||
* headache | |||
* dizziness | |||
* flushing | |||
* hypotension | |||
* reflex tachycardia | |||
*edema | |||
==Pharmacology== | ==Pharmacology== | ||
Revision as of 22:23, 5 April 2015
General
- Type: stimulates cGMP production causing vascular smooth muscle relaxation
- Dosage Forms: SL, IV
- Common Trade Names: Nitrolingual, NitroMist, Nitrostat
Adult Dosing
- Angina, Acute: 0.3 - 0.6 mg SL q5min x 3 doses max
- HTN/CHF: 5-200 mcg/min IV, start 5 mcg/min IV
Pediatric Dosing
HTN/CHF: 1-5 mcg/kg/min IV, start 0.25-0.5 mcg/kg/min, max: 20 mcg/kg/min
Special Populations
- Pregnancy Rating: C
- Lactation: safety unknown
- Renal Dosing
- Adult: no adjustment
- Pediatric: no adjustment
- Hepatic Dosing
- Adult: not defined
- Pediatric: not defined
Contraindications
- Allergy to class/drug
- Pericardial tamponade
- severe anemia
- sildenafil use
- methemoglobinemia
- caution if hypotension
Adverse Reactions
Serious
- hypotension
- bradycardia
- methemoglobinemia
Common
- headache
- dizziness
- flushing
- hypotension
- reflex tachycardia
- edema
Pharmacology
- Half-life:
- Metabolism:
- Excretion:
- Mechanism of Action: