Aspirin: Difference between revisions

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==Adult Dosing==
==Adult Dosing==
*325 to 650 mg PO or PR q4 hours PRN
*325 to 650 mg orally or rectally every 4 hours as needed, not to exceed 4 g/day
**Do not exceed 4 g/day
*324 mg chewable for ACS
*324 mg chewable for ACS
*81 mg (baby) aspirin common daily cardiac risk reduction dose
*81 mg (baby) Aspirin common daily cardiac risk reduction dose


==Pediatric Dosing==
==Pediatric Dosing==
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**Hives, Facial swelling, Asthma, Shock
**Hives, Facial swelling, Asthma, Shock
*Bleeding, Ulcers, Asthma
*Bleeding, Ulcers, Asthma
* G6PD deficiency
*[[Glucose-6-Phosphate Deficiency (G6PD)]]


==Adverse Reactions==
==Adverse Reactions==
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*[[Aspirin (Salicylate) Toxicity]]
*[[Aspirin (Salicylate) Toxicity]]
*[[Reye syndrome]] - Children and teenagers should not use this medicine for chicken pox or flu symptoms  
*[[Reye syndrome]] - Children and teenagers should not use this medicine for chicken pox or flu symptoms  
* bleeding
 
* bronchospasm
* GI ulcer
* pancytopenia
* agranulocytosis
===Common===
===Common===
* nausea/vomiting
 
* abdominal pain
* rash
* tinnitus
* diarrhea


==Pharmacology==
==Pharmacology==
*Half-life: 0.25h, 2 - 6 hour salicylate
*Half-life:  
*Metabolism: Gut and plasma, Liver
*Metabolism:  
*Excretion: urine
*Excretion:  
*Mechanism of Action: non-selectively and irreversibly inhibits cyclooxygenase
*Mechanism of Action:


==See Also==
==See Also==

Revision as of 21:17, 3 April 2015

General

  • Type: Antiplatelet
  • Dosage Forms:
  • Common Trade Names: Aspirin, Baby Aspirin, ASA
  • Usage:
    • Pain reliever/fever reducer
    • Antiplatelet

Adult Dosing

  • 325 to 650 mg orally or rectally every 4 hours as needed, not to exceed 4 g/day
  • 324 mg chewable for ACS
  • 81 mg (baby) Aspirin common daily cardiac risk reduction dose

Pediatric Dosing

  • 2 to 11 years: 10 to 15 mg/kg orally or rectally every 4 to 6 hours as needed, not to exceed 4 g/day.
  • 12 years or older: 325 to 650 mg orally or rectally every 4 hours as needed, not to exceed 4 g/day

Special Populations

  • Pregnancy Rating: D
  • Lactation: best avoided, low dose may be considered for antiplatelet
  • Renal Dosing
    • Adult: if CrCl<10, avoid use
    • Pediatric: if CrCl<10, avoid use
  • Hepatic Dosing
    • Adult: not defined
    • Pediatric: not defined

Contraindications

Adverse Reactions

Serious

Common

Pharmacology

  • Half-life:
  • Metabolism:
  • Excretion:
  • Mechanism of Action:

See Also

Sources

http://www.drugs.com/aspirin.html