Aspirin

General

• Type: Antiplatelet
• Dosage Forms:
• Common Trade Names: Aspirin, Baby Aspirin, ASA
• Usage:
  • Pain reliever/fever reducer
  • Antiplatelet

Adult Dosing

• 325 to 650 mg PO or PR q4 hours PRN
  • Do not exceed 4 g/day
• 324 mg chewable for ACS
• 81 mg (baby) aspirin common daily cardiac risk reduction dose

Pediatric Dosing

• 2 to 11 years: 10 to 15 mg/kg orally or rectally every 4 to 6 hours as needed, not to exceed 4 g/day.
• 12 years or older: 325 to 650 mg orally or rectally every 4 hours as needed, not to exceed 4 g/day

Special Populations

• Pregnancy Rating: D
• Lactation: best avoided, low dose may be considered for antiplatelet
• Renal Dosing
  • Adult: if CrCl<10, avoid use
  • Pediatric: if CrCl<10, avoid use
• Hepatic Dosing
  • Adult: not defined
  • Pediatric: not defined

Contraindications

• Allergy to class/drug
  • Hives, Facial swelling, Asthma, Shock
• Bleeding, Ulcers, Asthma
• G6PD deficiency

Adverse Reactions

Serious

• Aspirin (Salicylate) Toxicity
• Reye syndrome - Children and teenagers should not use this medicine for chicken pox or flu symptoms
• bleeding
• bronchospasm
• GI ulcer
• pancytopenia
• agranulocytosis

Common

• nausea/vomiting
• abdominal pain
• rash
• tinnitus
• diarrhea

Pharmacology

• Half-life: 0.25h, 2 - 6 hour salicylate
• Metabolism: Gut and plasma, Liver
• Excretion: urine
• Mechanism of Action: non-selectively and irreversibly inhibits cyclooxygenase

See Also

• Aspirin (Salicylate) Toxicity

Sources

http://www.drugs.com/aspirin.html