Ibuprofen: Difference between revisions
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==Pharmacology== | ==Pharmacology== | ||
*Half-life: | *Half-life: 1.8 - 2 hr | ||
*Metabolism: | *Metabolism: liver | ||
*Excretion: | *Excretion: Urine | ||
*Mechanism of Action: | *Mechanism of Action: exact mechanism unknown; inhibits cyclooxygenase, reducing prostaglandin and thromboxane synthesis | ||
==See Also== | ==See Also== | ||
Revision as of 19:50, 28 March 2015
General
- Type: NSAID
- Dosage Forms:
- Common Trade Names: Advil; Motrin
Adult Dosing
- 600mg PO Q6hours
Pediatric Dosing
- 10 mg/kg PO Q6hours
- Max: 40 mg/kg/day
Special Populations
- Pregnancy Rating: B
- Lactation: Safe
- Renal Dosing
- Adult: no adjustment
- Pediatric: no adjustment
- Hepatic Dosing
- Adult: not defined
- Pediatric: not defined
Contraindications
- Allergy to class/drug
- Cardiovascular
- May cause an increased risk of serious cardiovascular thrombotic events, myocardial infarction, and stroke, which can be fatal
- Contraindicated for treatment of perioperative pain in the setting of coronary artery bypass graft (CABG) surgery
- Gastrointestinal risk
- Increased risk of serious gastrointestinal (GI) adverse events including bleeding, ulceration, and perforation of the stomach or intestines, which can be fatal
- Elderly patients are at greater risk for serious GI events.
- Increased risk of serious gastrointestinal (GI) adverse events including bleeding, ulceration, and perforation of the stomach or intestines, which can be fatal
Adverse Reactions
Serious
- GI bleeding
- ulceration and perforation of the stomach or intestines
- thromboycytopenia
- agranulocytosis
- steven johnson syndrome
- nephrotoxicity
Common
- dyspepsia
- nausea
- abdominal pain
- constipation
- headache
- dizziness
- rash
- fluid retention
- ecchymosis
Pharmacology
- Half-life: 1.8 - 2 hr
- Metabolism: liver
- Excretion: Urine
- Mechanism of Action: exact mechanism unknown; inhibits cyclooxygenase, reducing prostaglandin and thromboxane synthesis