Ibuprofen: Difference between revisions
| Line 34: | Line 34: | ||
*[[GI bleeding]] | *[[GI bleeding]] | ||
*ulceration and perforation of the stomach or intestines | *ulceration and perforation of the stomach or intestines | ||
* thromboycytopenia | |||
* agranulocytosis | |||
* steven johnson syndrome | |||
* nephrotoxicity | |||
===Common=== | ===Common=== | ||
Revision as of 19:48, 28 March 2015
General
- Type: NSAID
- Dosage Forms:
- Common Trade Names: Advil; Motrin
Adult Dosing
- 600mg PO Q6hours
Pediatric Dosing
- 10 mg/kg PO Q6hours
- Max: 40 mg/kg/day
Special Populations
- Pregnancy Rating: B
- Lactation: Safe
- Renal Dosing
- Adult: no adjustment
- Pediatric: no adjustment
- Hepatic Dosing
- Adult: not defined
- Pediatric: not defined
Contraindications
- Allergy to class/drug
- Cardiovascular
- May cause an increased risk of serious cardiovascular thrombotic events, myocardial infarction, and stroke, which can be fatal
- Contraindicated for treatment of perioperative pain in the setting of coronary artery bypass graft (CABG) surgery
- Gastrointestinal risk
- Increased risk of serious gastrointestinal (GI) adverse events including bleeding, ulceration, and perforation of the stomach or intestines, which can be fatal
- Elderly patients are at greater risk for serious GI events.
- Increased risk of serious gastrointestinal (GI) adverse events including bleeding, ulceration, and perforation of the stomach or intestines, which can be fatal
Adverse Reactions
Serious
- GI bleeding
- ulceration and perforation of the stomach or intestines
- thromboycytopenia
- agranulocytosis
- steven johnson syndrome
- nephrotoxicity
Common
Pharmacology
- Half-life:
- Metabolism:
- Excretion:
- Mechanism of Action: