Acyclovir: Difference between revisions

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==Adult Dosing==
==Adult Dosing==
*HSV Encephalitis
**10 mg/kg IV q8h x 10 d
*Genital/Mucocutaneous HSV
**Immunocompetent
***1st episode, Mild-mod: 400 mg PO TID x 7-10 d
***1st episode, Severe: 5-10 mg/kg IV q8h x 2-7 d
***Recurrence: 400 mg PO TID x 5 d
***Suppression: 400 mg PO BID
**Immunocompromised
***1st episode: 400 mg PO TID x 5-10 d
***Recurrence: 400 mg PO TID x 5-10 d
***Suppression: 400-800 mg PO BID-TID
*Varicella
**Immunocompetent
***800 mg PO QID x 5-7 d
**Immunocompromised
***10 mg/kg IV q8h x 7 d
*Herpes Zoster
**Immunocompetent
***800 mg PO 5x/day x 7 d
**Immunocompromised
***10 mg/kg IV q8h x 7 d
*Zoster Ophthalmicus
**800 mg PO 5x/day x 7 d
*HSV prophylaxis in immunocompromised
**400-800 mg PO BID-TID
*HSV keratitis
**400 mg PO 5x/day


==Pediatric Dosing==
==Pediatric Dosing==

Revision as of 22:24, 4 March 2015

General

  • Type:
  • Dosage Forms: IV, PO
  • Common Trade Names: Zovirax

Adult Dosing

  • HSV Encephalitis
    • 10 mg/kg IV q8h x 10 d
  • Genital/Mucocutaneous HSV
    • Immunocompetent
      • 1st episode, Mild-mod: 400 mg PO TID x 7-10 d
      • 1st episode, Severe: 5-10 mg/kg IV q8h x 2-7 d
      • Recurrence: 400 mg PO TID x 5 d
      • Suppression: 400 mg PO BID
    • Immunocompromised
      • 1st episode: 400 mg PO TID x 5-10 d
      • Recurrence: 400 mg PO TID x 5-10 d
      • Suppression: 400-800 mg PO BID-TID
  • Varicella
    • Immunocompetent
      • 800 mg PO QID x 5-7 d
    • Immunocompromised
      • 10 mg/kg IV q8h x 7 d
  • Herpes Zoster
    • Immunocompetent
      • 800 mg PO 5x/day x 7 d
    • Immunocompromised
      • 10 mg/kg IV q8h x 7 d
  • Zoster Ophthalmicus
    • 800 mg PO 5x/day x 7 d
  • HSV prophylaxis in immunocompromised
    • 400-800 mg PO BID-TID
  • HSV keratitis
    • 400 mg PO 5x/day

Pediatric Dosing

Special Populations

  • Pregnancy Rating:
  • Lactation:
  • Renal Dosing
    • Adult
    • Pediatric
  • Hepatic Dosing
    • Adult
    • Pediatric

Contraindications

  • Allergy to class/drug

Adverse Reactions

Serious

Common

Pharmacology

  • Half-life:
  • Metabolism:
  • Excretion:
  • Mechanism of Action:

See Also

Sources