Warfarin: Difference between revisions

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2.0-3.0: all other indications
2.0-3.0: all other indications


==Reversal==
==Reversal==
#FFP (10-20/kg) to decr INR to 1.5 (should occur in 6-24 hr)
[[Warfarin (Coumadin) Reversal]]
#+/- Vitamin K (10 mg IM) (takes 24hrs to affect & 2wk to wear off)
 
==Potentiators==


==Source ==
==Source ==

Revision as of 06:23, 4 July 2011

Dosing

  1. Day 1: 5 to 7.5 mg po at night (to ensure absorption on an empty stomach),
  2. Day 2, 3, 4...: 2.5 to 7.5 mg po qhs (most often 5 mg)
  • An increase in INR of >0.3-0.4 units per day necessitates dose reduction
  • CHF, liver disease, Vitamin K def, drugs may influence warfarin response

Range (INR)

2.5 to 3.5: mechanical prosthetic valves or recurrent thromboembolism

2.0-3.0: all other indications

Reversal

Warfarin (Coumadin) Reversal

Source

1/26/06 DONALDSON (addapted from Lampe), EMP 1/11