Neuromuscular blocking agents: Difference between revisions
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|[[Atracurium]] (Tracrium) | |[[Atracurium]] (Tracrium) | ||
|90 | |90 | ||
|30 min or less | |30 min or less | ||
| | | | ||
*[[hypotension]] | *Transient [[hypotension]] | ||
*Toxic metabolite | *Toxic metabolite (laudanosine), greater accumulation in individuals with renal failure | ||
|- | |- | ||
|[[Vecuronium]] (Norcuron) | |[[Vecuronium]] (Norcuron) | ||
| Line 39: | Line 39: | ||
|45–70 | |45–70 | ||
|may promote muscarinic block | |may promote muscarinic block | ||
|- | |- | ||
|[[Pancuronium]] (Pavulon) | |[[Pancuronium]] (Pavulon) | ||
Revision as of 03:34, 24 February 2015
Background
- Non-depolarizing
- Competitively block binding of ACh to its receptors
- Depolarizing
- Depolarizing skeletal muscle fiber
- Persistent depolarization makes the muscle fiber resistant to further stimulation by ACh
Types
| Agent | Time to onset (seconds) | Duration (minutes) | Side effects |
|---|---|---|---|
| Non-Depolarizing | |||
| Succinylcholine | fasciculations, post-operative pain | ||
| Depolarizing | |||
| Atracurium (Tracrium) | 90 | 30 min or less |
|
| Vecuronium (Norcuron) | 60 | 30–40 | Few, may cause prolonged paralysis and promote muscarinic block |
| Rocuronium (Zemuron) | 75 | 45–70 | may promote muscarinic block |
| Pancuronium (Pavulon) | 90 | 180 or more |
|