Neuromuscular blocking agents: Difference between revisions

Revision as of 03:33, 24 February 2015

Non-depolarizing
- Competitively block binding of ACh to its receptors
Depolarizing
- Depolarizing skeletal muscle fiber
- Persistent depolarization makes the muscle fiber resistant to further stimulation by ACh

Neuromuscular Blocking Agents
Agent	Time to onset (seconds)	Duration (minutes)	Side effects
Non-Depolarizing
Succinylcholine			fasciculations, post-operative pain
Depolarizing
Atracurium (Tracrium)	90	30 min or less^[1]	hypotension, transiently,^[1] by release of histamine Toxic metabolite called laudanosine, greater accumulation in individuals with renal failure
Vecuronium (Norcuron)	60	30–40	Few, may cause prolonged paralysis and promote muscarinic block
Rocuronium (Zemuron)	75	45–70	may promote muscarinic block
Pancuronium (Pavulon)	90	180 or more	tachycardia (slight) (no hypotension)

↑ ^1.0 ^1.1 Cite error: Invalid <ref> tag; no text was provided for refs named Rang151

Authors:

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 |+Neuromuscular Blocking Agents
 !Agent
-|'''Time to onset''' <br> (seconds)
+!'''Time to onset''' (seconds)
-|'''Duration''' <br> (minutes)
+!'''Duration''' (minutes)
 !Side effects
-!Clinical use
 |-
 | '''Non-Depolarizing'''
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 |
 *[[tachycardia]] (slight)
-(no hypotension)
+*(no hypotension)
 |-
 |}