Amphetamines: Difference between revisions

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==Background==
==Background==
- central action- increase release & decrease reuptak of dopamine & seratonin. Leads to euphoria & strength
- perif action- facilitate synaptic xmission @ spinal cord by unknown mech
- also cause release of norepi- leads to alpha & beta stim
==Diagnosis==
===Alpha===
- pupils dilate
- sweat
- decrease gi peristalsis
- constrict blood vessels
===Beta===
- inc HR and contractility
- dilate bronchi
- dilate muscle beds
===Mixed===
- delusions, paranoia, aggression, poor judgement, hallucinate, confusion
==Treatment==
Benzos
==Theraputic Uses==
# appetite suppression
# inc alertness
# narcolepsy
# adhd
# inc mood
# avoid boredom on repetitive task jobs
==Types==
===General===
- Time- oral- 30min, inhaled instant
- Time- oral- 30min, inhaled instant


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- tolerance developes to positve and neg effects with inc use
- tolerance developes to positve and neg effects with inc use
===Theraputic Uses===
# appetite suppression
# inc alertness
# narcolepsy
# adhd
# inc mood
# avoid boredom on repetitive task jobs
==Diagnosis==
===Alpha===
- pupils dilate
- sweat
- decrease gi peristalsis
- constrict blood vessels
===Beta===
- inc HR and contractility
- dilate bronchi
- dilate muscle beds
===Mixed===
- delusions, paranoia, aggression, poor judgement, hallucinate, confusion
==Treatment==
Benzos


==Source==
==Source==

Revision as of 20:22, 11 June 2011

Background

- Time- oral- 30min, inhaled instant

- hepatic and renal excretion- lasts 6- 24 hrs

- if tolerance developes- physical exam may yield normal findings

- desipramine and amantadine can give false positive for urine amphet test

- hallucinogenic amphet deriv may not show up on tox screen AKA Entactogens- enabling user to touch within

Meth Amphet

- more combative- delusions of parasites- formication\ self mutilate

- more dysphoric

- AKA ice crystal speed go crank

MDMA Ecstacy

- changes 5HT neuroxmitter

- inc dopamine

- lasts 3 - 5hrs

- usual dose for psychgTx- 50 - 200mg

- cardiac effects

- euphoria- interpersonal clgseness- introspection

- enhanced socialibility (rave)

- deep empathy

- severe withdrawal with anxiety and depression

- tolerance developes to positve and neg effects with inc use

Theraputic Uses

  1. appetite suppression
  2. inc alertness
  3. narcolepsy
  4. adhd
  5. inc mood
  6. avoid boredom on repetitive task jobs


Diagnosis

Alpha

- pupils dilate

- sweat

- decrease gi peristalsis

- constrict blood vessels

Beta

- inc HR and contractility

- dilate bronchi

- dilate muscle beds

Mixed

- delusions, paranoia, aggression, poor judgement, hallucinate, confusion

Treatment

Benzos

Source

MISTRY 6/06