Dopamine: Difference between revisions
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==Adult Dosing== | ==Adult Dosing== | ||
===Dosing=== | |||
*Low dose: | |||
**1-5 mcg/kg/min - Vasodilation (renal, mesenteric, coronary) | |||
**5-10 mcg/kg/min - predominant β1 | |||
*High dose: 10-20 mcg/kg/min - predominant α1 | |||
*Titrate to clinical effect | |||
**Use lowest dose possible (prevent tachyphylaxis) | |||
*May use in peripheral IV temporarily | |||
**Avoid using in same line as alkaline infusions | |||
===Rate of Titration=== | |||
*Q2-5 min | |||
==Pediatric Dosing== | ==Pediatric Dosing== | ||
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==Contraindications== | ==Contraindications== | ||
*Allergy to class/drug | *Allergy to class/drug | ||
*Tachyarrhythmias | |||
==Adverse Reactions== | ==Adverse Reactions== | ||
*Low doses: | |||
**Hypotension | |||
*High doses: | |||
**Hypertension, ectopic beats | |||
*Tissue necrosis (if extravasates) | |||
**If occurs use phentolamine 5-10mg in affected area | |||
===Serious=== | ===Serious=== | ||
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*Excretion: | *Excretion: | ||
*Mechanism of Action: | *Mechanism of Action: | ||
===Primary Receptor=== | |||
* Low dose: DA, β1 | |||
* High dose: DA, α1 >> β1 | |||
===Relative Effects=== | |||
*Low dose: Natriuresis, ↑↑HR, ↑↑SV | |||
*High dose: ↑SVR and ↑SV | |||
==Notes== | |||
===Indications=== | |||
*Hypotension caused by: | |||
**Septic shock | |||
**MI | |||
**Trauma/spinal shock | |||
**Heart failure | |||
==See Also== | ==See Also== | ||
Revision as of 14:09, 20 December 2014
General
- Type: Vasopressors
- Dosage Forms:
- Common Trade Names:
Adult Dosing
Dosing
- Low dose:
- 1-5 mcg/kg/min - Vasodilation (renal, mesenteric, coronary)
- 5-10 mcg/kg/min - predominant β1
- High dose: 10-20 mcg/kg/min - predominant α1
- Titrate to clinical effect
- Use lowest dose possible (prevent tachyphylaxis)
- May use in peripheral IV temporarily
- Avoid using in same line as alkaline infusions
Rate of Titration
- Q2-5 min
Pediatric Dosing
Special Populations
- Pregnancy Rating:
- Lactation:
- Renal Dosing
- Adult
- Pediatric
- Hepatic Dosing
- Adult
- Pediatric
Contraindications
- Allergy to class/drug
- Tachyarrhythmias
Adverse Reactions
- Low doses:
- Hypotension
- High doses:
- Hypertension, ectopic beats
- Tissue necrosis (if extravasates)
- If occurs use phentolamine 5-10mg in affected area
Serious
Common
Pharmacology
- Half-life:
- Metabolism:
- Excretion:
- Mechanism of Action:
Primary Receptor
- Low dose: DA, β1
- High dose: DA, α1 >> β1
Relative Effects
- Low dose: Natriuresis, ↑↑HR, ↑↑SV
- High dose: ↑SVR and ↑SV
Notes
Indications
- Hypotension caused by:
- Septic shock
- MI
- Trauma/spinal shock
- Heart failure